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目的:研究中西医结合治疗对急性缺血性脑卒中患者血清肿瘤坏死因子(TNF-α)、高敏反应蛋白(hs-CRP)、白细胞介素-6(IL-6)和神经功能的影响。方法:选择2010年2月~2015年12月我院急性缺血性脑卒中患者81例,随机分为两组。对照组静脉滴注低分子右旋糖苷、丹红、胞磷胆碱,观察组联合口服益气活血、醒脑涤痰中药汤剂。分别在治疗前和治疗14 d后,检测血清TNF-α、hs-CRP、IL-6水平,并用美国国立卫生研究院卒中量表(NIHSS)对神经功能进行评价。结果:观察组的有效率明显高于对照组(P<0.05);两组治疗后TNF-α、hs-CRP和IL-6水平均明显降低(P<0.05),且观察组明显更低(P<0.05);两组治疗后NIHSS评分均明显降低(P<0.05),且观察组明显更低(P<0.05)。结论:中西医结合治疗能降低急性缺血性脑卒中患者TNF-α、hs-CRP、IL-6水平,明显改善患者神经功能。
Objective: To study the effects of integrated traditional Chinese and western medicine on the serum levels of tumor necrosis factor (TNF-α), high-sensitivity protein (hs-CRP), interleukin-6 (IL-6) and neurological function in patients with acute ischemic stroke. Methods: From February 2010 to December 2015, 81 patients with acute ischemic stroke in our hospital were randomly divided into two groups. Control group intravenous infusion of low molecular weight dextran, Dan Hong, citicoline, observation group combined oral Yiqihuoxue, Xingnao Ditan traditional Chinese medicine decoction. Serum levels of TNF-α, hs-CRP and IL-6 were measured before treatment and after 14 days of treatment, respectively, and neurological function was evaluated using the National Institutes of Health Stroke Scale (NIHSS). Results: The effective rate of the observation group was significantly higher than that of the control group (P <0.05). The levels of TNF-α, hs-CRP and IL-6 in the two groups were significantly decreased P <0.05). NIHSS scores of both groups were significantly decreased (P <0.05), and the observation group was significantly lower (P <0.05). Conclusion: The combination of TCM and WM can reduce the levels of TNF-α, hs-CRP and IL-6 in patients with acute ischemic stroke and significantly improve the neurological function.