论文部分内容阅读
目的：：探讨高血压合并房颤患者随访2年的卒中发生率及其危险因素。方法：分析高血压合并房颤患者资料,根据2年随访事件中是否发生卒中分为卒中组和非卒中组。用单因素和多因素Cox回归模型分析影响高血压合并房颤患者卒中发生的独立危险因素。结果：入选568例高血压合并房颤患者,其中卒中组53例,非卒中组515例,2年卒中发生率为9．3%。卒中组年龄显著高于非卒中组(P<0．01)；卒中组女性、既往卒中史所占比例均高于非卒中组(P<0．05)；非卒中组接受抗高血压、抗凝、他汀类药物治疗比例均高于卒中组( P<0．05)；多因素Cox回归模型分析显示,年龄( HR=1．044,95%CI1．011~1．077)、女性(HR =1．893,95%CI1．169~3．121)、未接受抗高血压治疗(HR =1．966,95%CI1．009~3．801)、既往卒中史(HR=1．679,95%CI1．073~2．614)是高血压合并房颤患者2年卒中发生的独立危险因素。结论：年龄、女性、未接受抗高血压治疗和既往卒中史是高血压合并房颤患者2年卒中发生的独立危险因素。“,”OBJECTIVE: To explore the independent risk factors of the stroke for 2 years in the patients with hypertension ( HT) combined with atrial fibrillation ( AF) . METHODS: Data of HT and AF patients were retrospectively analyzed. The 568 patients were divided into the stroke group (n=53) and the non-stroke group (n=515) according to the results of 2 year follow-up. The pre-dictors of the stroke event for 2 years were identified by uni-and multi-variate Cox regression analysis with the baseline and therapeu-tic variables. RESULTS: The incidences of stroke event for 2 years were 9. 3%. Compared with the non-stroke group, in the stroke group there were more female patients (P<0. 05), the patients were older (P<0. 01) and had higher proportion of previous history of stroke (P<0. 01). More patients received the antihypertensive treatment, anticoagulation treatment and statins therapy in the non-stroke group (P<0. 05). Multi-variate Cox regression analysis showed that age (HR=1. 044, 95%CI1. 011~1. 077), male (HR=1. 893, 95%CI1. 169 ~3. 121), previous stroke history (HR=1. 679, 95%CI1. 073 ~2. 614), and no antihypertensive treatment (HR=1. 966, 95% CI1. 009~3. 801) were independent risk factors for the 2 year stroke event in the patients with HT and AF. CONCLUSION: Age, female, previous stroke history and no antihypertensive treatment are the independent risk factors for the 2 year stroke event in patients with HT and AF.