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目的:研究银杏叶提取物EGb761对硝酸甘油型大鼠偏头痛的影响并初步探讨其机制。方法:SD大鼠随机分为正常对照组、假手术组、模型组、EGb761低、中、高剂量组,EGb761组以相应剂量EGb761灌胃一周,假手术组和模型组给予等量纯化水灌胃,正常对照组不做处理。末次给药后皮下注射硝酸甘油建立偏头痛大鼠模型,假手术组注射等量生理盐水,记录小鼠前肢搔头的次数,测定血浆血小板聚集率(platelet aggregation rate,PAR)、5-羟色胺(5-hydroxytryptamine,5-HT)和一氧化氮(nitric oxide,NO)的含量和脑组织中5-HT和NO的含量。结果:与模型组相比,EGb761可显著减少偏头痛模型大鼠前肢搔头次数(P<0.01),可明显降低血浆中PAR和NO含量(P<0.01;P<0.001)和脑组织中NO含量(P<0.01),同时,EGb761可明显升高血浆和脑组织中5-HT含量(P<0.001;P<0.01)。结论:EGb761可以调节偏头痛大鼠PAR、NO、5-HT的水平,这可能是EGb761治疗偏头痛的机制之一。
Objective: To study the effect of Ginkgo biloba extract EGb761 on migraine in rats with nitroglycerin and to explore its mechanism. Methods: The SD rats were randomly divided into normal control group, sham operation group, model group, EGb761 low, medium and high dose groups, EGb761 group fed EGb761 at the corresponding dose for one week, sham operation group and model group were given equal amount of purified water irrigation Stomach, normal control group did not do treatment. The rats in the sham operation group were injected with the same amount of normal saline, the frequency of scratching the forelimb of the mice was recorded, and the platelet aggregation rate (PAR), serotonin 5-hydroxytryptamine, 5-HT) and nitric oxide (NO) and brain tissue contents of 5-HT and NO. Results: Compared with the model group, EGb761 could significantly reduce the frequency of forelimb scratching in migraine rats (P <0.01), and significantly decrease the levels of PAR and NO in plasma (P <0.01; P <0.001) (P <0.01). At the same time, EGb761 significantly increased the content of 5-HT in plasma and brain (P <0.001; P <0.01). Conclusion: EGb761 can regulate the levels of PAR, NO and 5-HT in migraine rats, which may be one of the mechanisms of EGb761 in the treatment of migraine.