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目的 :应用血管回声跟踪技术(ET)检测艾滋病患者高效抗反转录病毒疗法(HAART)治疗后颈动脉弹性,探讨ET对艾滋病患者HAART治疗后预防颈动脉粥样硬化的指导价值。方法 :应用血管回声跟踪技术跟踪描记HAART治疗后艾滋病患者50例及健康志愿者30例颈总动脉(CCA)的运动轨迹,测量其僵硬度(β),弹性系数(Ep),顺应性(AC)以及脉搏波传导速度(PWVβ),并测量颈动脉内-中膜厚度(IMT)。结果 :HAART治疗后艾滋病患者较健康志愿者测量颈动脉IMT稍增厚,但差异无明显统计学意义;β,Ep以及PWVβ均增高,AC降低,差异均有统计学意义。结论 :血管回声跟踪技术可评价艾滋病患者HAART治疗后颈动脉粥样硬化的早期改变。
Objective: To assess the carotid artery elasticity after HAART treatment in patients with AIDS by means of vascular echo tracing (ET), and to explore the guiding value of ET on prevention of carotid atherosclerosis after HAART in AIDS patients. Methods: The trajectory of common carotid arteries (CCA) in 50 AIDS patients and 30 healthy volunteers after HAART was traced by using the technique of vascular echo tracking. The changes of the stiffness (β), elasticity (Ep), compliance ) And pulse wave velocity (PWVβ) were measured and carotid intima-media thickness (IMT) was measured. Results: After the treatment of HAART, the IMT of carotid artery was slightly thicker than that of healthy volunteers, but the difference was not statistically significant. The levels of β, Ep and PWVβ were both increased and the AC was decreased. The difference was statistically significant. Conclusion: Echo-tracking can assess the early changes of carotid atherosclerosis in patients with AIDS after HAART.