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恶心呕吐是儿童斜视术后一种常见的并发症，我们试图采用枢丹（Ｏｎｄａｎｓａｔｒｏｎ）对其进行预防。选择择期行斜视矫正术患儿４０名，ＡＳＡⅠ级，随机分为两组，每组２０名。均采用氯胺酮静脉全麻。实验组于首次静注氯胺酮后１０分钟静注枢丹０．１ｍｇ／ｋｇ。对照组不使用枢丹。对两组患儿进行随访。实验组患儿均未呕吐，对照组呕吐者１３例，自觉恶心但未呕吐者２例。结果有极显著差异（Ｐ＜０．０１）。组间患儿一般情况、手术时间、麻醉药用量及清醒时间等均无统计学意义（Ｐ＞０．０５）。实验表明，枢丹可以有效预防儿童氯胺酮麻醉下斜视手术后恶心呕吐，有较高使用价值及临床意义。
Nausea and vomiting are a common complication of strabismus in children, and we tried to prevent it with Ondansatron. Choose elective strabismus surgery in children 40, ASA Ⅰ, were randomly divided into two groups of 20. All use of ketamine intravenous anesthesia. Experimental group in the first intravenous ketamine 10 minutes after intravenous injection of Dan Dan 0.1mg / kg. The control group did not use fentanyl. Two groups of children were followed up. The experimental group did not vomit children, the control group, 13 cases of vomiting, nausea but not vomiting in 2 cases. The results were significantly different (P <0.01). There was no significant difference between the two groups in the general condition, operation time, anesthetic dosage and awake time (P> 0.05). Experiments show that, Shu Dan can effectively prevent children under ketamine anesthesia strabismus surgery after nausea and vomiting, with high value and clinical significance.