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目的观察氯沙坦联合其他抗高血压药物治疗原发性高血压病(高血压)的临床降压效果。方法把100例高血压患者随机分为氯沙坦组50例,口服氯沙坦50mg/d;依那普利组50例,口服依那普利5mg/d。两组于用药4周末,降压效果未达显效者,均联用吲达帕胺2·5mg/d,于4周末仍未达效者,再给予硝苯地平缓释片20mg/d4周。比较两组治疗前后血压、心率及实验室检查结果。结果氯沙坦组4、8、12周的降压有效率60%、78%、92%。而依那普利组为62%、80%、94%。两组比较差异无统计学意义(P>0·05),但氯沙坦组的干咳副作用发生率明显低于依那普利组(P<0·05)。结论氯沙坦和依那普利组降压效果基本相似,但氯沙坦组的干咳副作用明显低于依那普利组。
Objective To observe the effect of losartan combined with other antihypertensive drugs in the treatment of essential hypertension (hypertension). Methods 100 hypertensive patients were randomly divided into losartan group 50 cases, oral losartan 50mg / d; enalapril group 50 cases, oral enalapril 5mg / d. At the end of 4 weeks of treatment, the antihypertensive effects were not significantly effective in both groups. All the patients were treated with indapamide 2.5 mg once daily for 4 weeks, and were given nifedipine 20 mg / d for 4 weeks. Blood pressure, heart rate and laboratory test results before and after treatment were compared between the two groups. Results Losartan efficiency was 60%, 78% and 92% at 4, 8 and 12 weeks in losartan group. The enalapril group was 62%, 80%, 94%. There was no significant difference between the two groups (P> 0.05), but the incidence of dry cough and side effect in losartan group was significantly lower than that in enalapril group (P <0.05). Conclusion The antihypertensive effects of losartan and enalapril are similar, but the side effects of dry cough in losartan are obviously lower than that of enalapril.