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目的观察甲睾酮联合米非司酮治疗围绝经期子宫肌瘤的临床疗效。方法将60例患者随机分为治疗组和对照组,对照组给予口服米非司酮治疗,治疗组在对照组的基础上加服甲睾酮。3个月为1个疗程,连服2个疗程。6个月后随访月经及肌瘤变化情况,评价临床疗效。结果治疗组临床疗效总有效率为96.7%,高于对照组(80.0%),两组比较有统计学差异(P<0.05);经随访观察治疗组在诱导绝经及缩瘤的疗效稳定性方面优于对照组(P<0.05)。结论甲睾酮联合米非司酮能有效治疗围绝经期子宫肌瘤。
Objective To observe the clinical efficacy of methyltestosterone combined with mifepristone in the treatment of peri-menopausal uterine fibroids. Methods Sixty patients were randomly divided into treatment group and control group. The control group was treated with mifepristone. The treatment group was given methyltestosterone on the basis of the control group. 3 months for a course of treatment, and even served 2 courses. Six months after follow-up menstrual and fibroid changes, evaluation of clinical efficacy. Results The total effective rate in the treatment group was 96.7%, which was higher than that in the control group (80.0%). There was significant difference between the two groups (P <0.05). The follow-up observation showed that in the treatment group, Better than the control group (P <0.05). Conclusion Methyltestosterone combined with mifepristone can effectively treat perimenopausal uterine fibroids.