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目的通过研究信号转导和转录激活因子6(STAT6)基因多态性与变应性鼻炎的相关性,探讨STAT6链上1570C/T位点基因多态性与变应性鼻炎发病之间的关系。方法采用聚合酶链反应-限制性片段长度多态性分析法(PCR-RFLP)检测92例变应性鼻炎患者(病例组)和422例健康人群(对照组)的STAT6基因1570C/T位点多态性,比较两组的基因型和等位基因的分布频率。结果病例组TT、CT和CC基因型分布频率分别为5.43%、70.65%和23.91%;而对照组TT、CT和CC基因型分布频率分别为4.48%、75%和20.05%,两组的基因型分布频率和T1570和C1570等位基因分布频率均无差异(P=0.644、P=0.724)。结论病例组和对照组之间的STAT6基因1570C/T多态性基因型频率差异无统计学意义,提示STAT6(1570C/T)基因多态性与变应性鼻炎可能没有相关性。
Objective To investigate the relationship between polymorphism of signal transducer and activator of transcription 6 (STAT6) gene and allergic rhinitis and to explore the relationship between gene polymorphism of 1570C / T in STAT6 chain and the incidence of allergic rhinitis . Methods The STAT70 1570C / T locus in 92 patients with allergic rhinitis (case group) and 422 healthy people (control group) were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) Polymorphism, genotype and allele frequencies were compared between the two groups. Results The distribution frequencies of TT, CT and CC genotypes were 5.43%, 70.65% and 23.91% in the case group, while those in the control group were 4.48%, 75% and 20.05%, respectively Type distribution frequency and T1570 and C1570 allele distribution frequency were no difference (P = 0.644, P = 0.724). Conclusion There was no significant difference in the frequency of 1570C / T polymorphism of STAT6 gene between the case group and the control group, suggesting that the polymorphism of STAT6 (1570C / T) may not be related to allergic rhinitis.