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目的观察川穹嗪注射液在新生儿缺氧缺血性脑病中的治疗作用。方法将40例新生儿缺氧缺血性脑病患儿随机分为两组,每组各20例。对照组按照新生儿缺氧缺血性脑病标准方案治疗,干预组在标准方案基础上加用川穹嗪注射液治疗。结果干预组患者3周后脑电图检查与对照组比较差异无统计学意义(χ2=0.11,P>0.05);两组治疗后肌酸激酶脑型同工酶(CK-BB)浓度比较差异有统计学意义(χ2=4.82,P<0.05)。结论川穹嗪注射液能减轻缺氧缺血性脑病患儿的大脑损伤,但是对长期预后的改善作用还需要进一步研究。
Objective To observe the therapeutic effect of chuanadu injection in neonatal hypoxic-ischemic encephalopathy. Methods Forty neonates with hypoxic-ischemic encephalopathy were randomly divided into two groups, 20 cases in each group. The control group was treated according to the standard protocol of neonatal hypoxic-ischemic encephalopathy. The intervention group was treated with chuanadu injection on the basis of the standard protocol. Results There was no significant difference in electroencephalogram (EKG) between the intervention group and the control group after 3 weeks (χ2 = 0.11, P> 0.05). There was significant difference in creatine kinase (CK-BB) Statistical significance (χ2 = 4.82, P <0.05). Conclusion Chuanadumu injection can reduce brain damage in children with hypoxic-ischemic encephalopathy, but the improvement of long-term prognosis needs further study.