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4.3ROCKs和血管平滑肌细胞的增殖用Y-27632抑制ROCK后,血小板源生长因子(PDGF)BB诱导的细胞外调节激酶1/2(ERK1/2)的激活和血管平滑肌细胞的增殖也受到抑制,说明ROCK参与了PDGF诱导的平滑肌细胞增殖过程[53]。同样,凝血酶和尾加压素Ⅱ诱导的血管平滑肌细胞增殖也可以被ROCK阻滞
Proliferation ofROCKs and Vascular Smooth Muscle Cells The activation of extracellular regulated kinase 1/2 (ERK1 / 2) induced by platelet derived growth factor (PDGF) BB and the proliferation of vascular smooth muscle cells were also inhibited by the inhibition of ROCK with Y-27632, ROCK involved in PDGF-induced smooth muscle cell proliferation process [53]. Similarly, thrombin and urotensin II-induced vascular smooth muscle cell proliferation can also be ROCK block