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目的:在不同耐力训练的模型下,探讨SD.大鼠骨骼肌肌浆网的钙离子转运功能的变化。方法:采用实验法。实验选用2月龄纯种雄性SD.大鼠34只,随机分组。对实验对象采用小动物跑台进行递增耐力负荷训练,达到耐力训练模型标准后,再采用减量耐力训练,主要减少运动强度训练。使用荧光分光光度计对各组实验大鼠骨骼肌肌浆网Ca2+钙离子泵,RyR1受体进行测定。结果:耐力训练组肌浆网肌浆网钙离子泵、RyR1受体功能呈显著性增加(p<0.01)。4周以上减训钙离子泵、RyR1受体功能显著性下降(p<0.01)。结论:耐力训练增强骨骼肌肌浆网钙泵和RyR1受体的功能。4周及以后减训肌浆网钙泵和RyR1受体的功能性明显下降。
OBJECTIVE: To explore the changes of Ca2 + transport function in skeletal muscle sarcoplasmic reticulum of SD rats under different endurance training models. Methods: Using experimental method. Two-month-old male SD rats were randomly divided into three groups. The experimental object using small animal treadmill training to increase the endurance load to reach the endurance training model standards, and then reduce the amount of endurance training, the main reduction in exercise intensity training. Fluorescence spectrophotometer was used to determine the sarcoplasmic reticulum Ca2 + Ca2 + pump and RyR1 receptor in the experimental rats. Results: The endurance training group sarcoplasmic sarcoplasmic reticulum calcium pump, RyR1 receptor function was significantly increased (p <0.01). After 4 weeks of training, the function of RyR1 receptor decreased significantly (p <0.01). Conclusion: Endurance training enhances the function of skeletal muscle sarcoplasmic reticulum calcium pump and RyR1 receptor. Four weeks and later reduced sarcoplasmic reticulum calcium pump and RyR1 receptor function decreased significantly.