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目的 对非线性血液滞后环曲线应用连续反应动力学方程进行数值解.方法 应用力学滞后环的测定技术,将血液样品在三角单波切变率作用下,对其滞后环进行测定,建议其上升线解散为单个红细胞,其下降线由单个红细胞复聚为缗钱体的双相过程中,存在着有中间体出现的过程,应用连续化学反应动力学对非线性血液滞后环的拟合与数值解.结果 得出了8个方程参数来描述整个血液滞后环曲线:即k1(中间体生成的速度常数)、k2(中间体耗竭成为单个红细胞的速度常数)、k3(由单个红细胞复原为中间体的速度常数)、k4(由中间体复原为缗钱体的速度常数)、ηN(牛顿黏度分值)、ηY(屈服应力生成常数)、τ0(屈服应力绝对值)、τM(最大切应力值).从上述8个参数中提取出其中3个具有明显可描述血液滞后环的特点参数,即:k4、ηN、τ0.结论 该文不仅应用连续反应动力学方程进行数值解并描写了血液滞后环的性质,而且研究了健康人群和缺血性中风人群血液滞后环参数上的区别,为脑血管病的临床应用提供了理论与实验资料.“,”Objective Our article tried to make a digital solution for blood non-linear hysteresis loop curves by continuous chemical reaction kinetics. Methods This article introduces test technique and basic theory for blood hysteresis loops. The article suggests the intermediate product in tested blood system should be appeared under the double-phase reaction of a given shear rate mono-triangular wave that: when shear rate is increasing, which makes RBC rouleaus become single RBCs, and when shear rate is decreasing, which makes single RBCs re-aggregate the RBC rouleaus. Results The article realized imitation of continuous chemical reaction kinetics for blood non-linear hysteresis loop curves and obtained 8 parameters to describe the characterization, such as k1 (velocity constant of intermediate products formation from RBC rouleaus), k2 (velocity constant of intermediate products to be degraded into single RBCs), k3 (velocity constant of re-formation of intermediate products from single RBCs), k4 (velocity constant of reformation of RBC rouleaus from intermediate products), ηN (fraction of Newtonian viscosity coefficient), ηY (yield stress formation equation constant), τ0 (yield stress) and τM(maximum stress). Among the 8 parameters, we extract 3 important ones which show main physical meanings for blood hysteresis loops and the differentiations between health control group and ischemic stroke patient group, ie. k4. ηN and τ0. We also tested the differentiation of parameters values between healthy group and patient group. Conclusion Our results show that not only do our model indicate the nature for blood hysteresis loops, but also point out the differentiation between health group and ischemic stroke patient group, which provides the basic theories and experimental data for application in medicine for cerebro-vascular diseases.