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目的探讨氨茶碱联合糖皮质激素对慢性阻塞性肺疾病(COPD)缓解期患者的治疗效果。方法将90例COPD缓解期患者随机分为对照组和观察组,各45例,对照组采取糖皮质激素药物吸入治疗,观察组在对照组基础上加以氨茶碱治疗,均干预3个月。比较两组治疗前后炎症因子、肺功能、运动耐量及生活质量情况。采用SPSS17.0统计软件进行统计分析,计量资料用均数±标准差(xˉ±s)表示,采用t检验,计数资料用率(%)表示,采用χ2检验,P<0.05表示差异有统计学意义。结果观察组与对照组治疗后在痰液白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α、(TNF-α)、第1 s用力呼吸容积(FEV1)、FEV1/用力肺活量(FVC)、6 min步行距离(6MWD)、圣乔治呼吸问卷(SGRQ)评分方面比较,差异均有统计学意义(P<0.05)。结论氨茶碱联合糖皮质激素治疗能明显改善COPD缓解期患者肺功能,提高其运动耐力及生活质量,这可能与药物抑制气道炎症反应有关。
Objective To investigate the therapeutic effect of aminophylline combined with glucocorticoid on patients with chronic obstructive pulmonary disease (COPD) remission. Methods Ninety patients with COPD were randomly divided into control group and observation group, 45 cases in each group. The control group was treated with glucocorticoid inhalation. The observation group was treated with aminophylline on the basis of the control group for 3 months. The inflammatory factors, lung function, exercise tolerance and quality of life before and after treatment were compared between the two groups. SPSS17.0 statistical software was used for statistical analysis. The measurement data were expressed as mean ± standard deviation (xˉ ± s). The t test was used to show the data usage rate (%). Chi-square test was used. P <0.05 means the difference was statistically significant significance. Results The levels of interleukin 6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), forced expiratory volume (FEV 1) , FEV1 / FVC, 6MWD, and SGRQ were all significantly different (P <0.05). Conclusion The combination of aminophylline and glucocorticoid can significantly improve pulmonary function and improve exercise endurance and quality of life in COPD patients, which may be related to the inhibition of airway inflammation by drugs.