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目的:研究莪术油注射液介入治疗早期高危子宫内膜癌的临床疗效。方法:将100例早期高危子宫内膜癌患者,随机分为对照组和治疗组,各50例。对照组采用CAP方案化疗,治疗组先给予莪术油注射液15 d,再改用CAP方案化疗。观察两组近期临床疗效、生活状态评价(Karnofsky和体重)及不良反应。结果:治疗组有效率为58.0%,高于对照组46.0%,差异有统计学意义(P<0.05);治疗组KPS评分改善率为92.0%,显著高于对照组74.0%;两组治疗前、后体重均有显著性变化,治疗后,治疗组高于对照组,差异均具有统计学意义(P<0.05);治疗组白细胞减少、恶心、呕吐不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论:化疗前给予莪术油注射液,可显著提高其临床疗效,改善患者生活质量。
Objective: To study the curative effect of Ezhu oil injection on early high risk endometrial carcinoma. Methods: 100 cases of early high-risk endometrial cancer patients were randomly divided into control group and treatment group, 50 cases each. Control group with CAP chemotherapy, the treatment group was given Curcuma oil injection 15 d, then switch to CAP regimen chemotherapy. The two groups were observed the recent clinical efficacy, life status assessment (Karnofsky and weight) and adverse reactions. Results: The effective rate of treatment group was 58.0%, higher than 46.0% of control group, the difference was statistically significant (P <0.05); the improvement rate of KPS score was 92.0% in treatment group, significantly higher than 74.0% in control group; (P <0.05). The incidence of leukopenia, nausea and vomiting in the treatment group was lower than that in the control group, the difference was statistically significant Statistical significance (P <0.05). Conclusion: Curcuma oil injection before chemotherapy can significantly improve its clinical efficacy and improve the quality of life of patients.