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目的研究新生儿坏死性小肠结肠炎(NEC)超早期表现,以便早期发现、早期诊断,预防典型NEC发病率,减少死亡率,提高生存质量。方法疑似NEC患儿150例随机分成两组,超早期诊断组和正常治疗组,各75例。超早期诊断组给予早期禁食,对症处理;正常治疗组按标准正常喂养,典型NEC诊断后均按标准治疗,观察两组患儿典型NEC的发生率,严重程度及预后。结果超早期诊断组Ⅱ期NEC发生4例,正常治疗组相Ⅱ期NEC发生16例,差异具有统计学意义(P<0.01);超早期诊断组Ⅲ期NEC发生0例,正常治疗组Ⅲ期NEC发生7例,差异具有统计学意义(P<0.01)。超早期诊断组与正常治疗组相比典型NEC的发生率明显降低且病情较轻,正常治疗组手术2例,两组均无死亡患儿。结论超早期诊断NEC能显著减少典型NEC的发生且有助于减轻病情。
Objective To study the ultra early manifestation of neonatal necrotizing enterocolitis (NEC) in order to detect and diagnose early, prevent the incidence of typical NEC, reduce the mortality and improve the quality of life. Methods 150 cases of suspected NEC children were randomly divided into two groups, ultra-early diagnosis group and normal treatment group, each 75 cases. Early ultra-early diagnosis group given early fasting, symptomatic treatment; normal treatment group normal standard feeding, typical NEC after diagnosis according to standard treatment, observed two groups of children with typical NEC incidence, severity and prognosis. Results There were 4 cases of NEC in ultra early diagnosis group, 16 cases of NEC in phase Ⅱ in normal treatment group, the difference was statistically significant (P <0.01) NEC occurred in 7 cases, the difference was statistically significant (P <0.01). Early ultrasonographic diagnosis group compared with the normal treatment group, the incidence of typical NEC was significantly reduced and mild disease, the normal treatment group surgery in 2 cases, no death in both groups. Conclusion Ultra-early diagnosis of NEC can significantly reduce the occurrence of typical NEC and help to reduce the disease.