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目的 :探讨自体骨髓移植对复发 难治急性白血病的治疗效果。方法 :选取 3例患者作为研究对象 ,3例患者中 ,急性淋巴细胞白血病 1例 ,急性髓细胞白血病 2例 ,初治时均以标准诱导化疗方案化疗 1疗程未达到完全缓解 (CR) ,第 2疗程重复诱导化疗方案后达到完全缓解 ,巩固化疗过程中 ,患者于第 6— 8疗程复发 (中位数第 7疗程 ) ,CR2 至ABMT的中位时间为 5月 ,预处理方案为CBV(即BCNU +CTX +VP 16 ) ,采集骨髓悬液约 2 5 0～ 880ml,中位数 5 90ml,含单个核细胞数为 1 5 4～ 2 3× 10 8 kg ,中位数 1 94× 10 8 kg ,采集后 4℃冰箱保存6 0小时。结果 :患者通过。细胞期 ,白细胞升至 0 5× 10 9 L的中位数时间为 2 7天 ,血小板计数上升至 2 0×10 9 L的中位数时间为 36天 ,骨髓恢复正常工作造血的中位数时间为 33天。结论 :自体骨髓移值是一种有价值的治疗方法。
Objective: To investigate the effect of autologous bone marrow transplantation on the treatment of relapsed and refractory acute leukemia. Methods: Three patients were selected as the research object. Among the three patients, 1 had acute lymphoblastic leukemia and 2 had acute myeloid leukemia. The initial induction therapy did not achieve complete remission (CR) after one course of chemotherapy with standard induction chemotherapy. Two courses of chemotherapy induced remission to achieve complete remission, consolidate the course of chemotherapy, patients relapsed on the 6th to 8th course of treatment (median 7 courses), CR2 to ABMT median time was 5 months, the pretreatment program for the CBV ( Namely BCNU + CTX + VP 16). The bone marrow suspension was collected from about 250 to 880 ml with a median of 5 90 ml. The number of mononuclear cells was from 154 to 23 × 10 8 kg with a median of 1 94 × 10 8 kg, collected after 4 ℃ refrigerator 60 hours. Results: Patient passed. In the cell stage, the median number of leukocytes up to 0 5 × 10 9 L was 27 days, the median platelet count increased to 20 × 10 9 L for 36 days, and the median bone marrow returned to normal working hematopoiesis The time is 33 days. Conclusion: Autologous bone marrow transplantation is a valuable treatment.