研究发现八角茴香(Illiciumverum)甲醇提取物对LPS/D-半乳糖胺诱导的脓毒症具有预防作用。本次以生物活性指导分离,从其甲醇提取物的正丁醇部分得到化合物1～6。干燥的八角茴香果实(9kg)用90%甲醇回流提取12h。甲醇溶液蒸干,残余物在水和己烷中分配。水层依次用乙酸乙酯和正丁 Studies have found that the Illicium verum methanol extract has a preventive effect on LPS/D-galactosamine induced sepsis. This time, the isolation was guided by biological activity, and compounds 1 to 6 were obtained from the n-butanol part of the methanol extract. The dried star anise fruits (9 kg) were reflux extracted with 90% methanol for 12 h. The methanol solution is evaporated to dryness and the residue is partitioned between water and hexane. The aqueous layer uses ethyl acetate and n-butyl