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人类许多肿瘤都与染色体异常有关。在滤泡型淋巴瘤中最常见的染色体异常是t(14:18)(q32:q21)易位。这一易位导致14号染色体上的免疫球蛋白重链基因(IgH)与18号染色体上bcl-2癌基因(B-cell lymphoma/leukemia-2 oncogene)的融合,使得bcl-2蛋白过度表达。 成都华西医科大学病理学教研室王洁等,利用PCR技术和免疫组化方法,对28例滤泡型淋巴瘤和18例反应性滤泡增生进行了bel-2/IgH融合基因和bcl-2蛋白表达进行检测。结果发现不仅57％的滤
Many human tumors are associated with chromosomal abnormalities. The most common chromosomal abnormality in follicular lymphoma is the t(14:18)(q32:q21) translocation. This translocation resulted in the fusion of the immunoglobulin heavy chain gene (IgH) on chromosome 14 with the B-cell lymphoma/leukemia-2 oncogene on chromosome 18, resulting in overexpression of bcl-2 protein. . Wang Jie et al., Department of Pathology, Chengdu West China Medical University, used PCR and immunohistochemistry to perform bel-2/IgH fusion gene and bcl-2 protein in 28 cases of follicular lymphoma and 18 cases of reactive follicular hyperplasia. Expression is tested. Results found not only 57% of the filter