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采用高转移肿瘤细胞对基底膜成分的体外粘附、侵袭模型和Lewis肺癌细胞自发肺转移模型 ,研究了YIGSR均叉、杂叉聚合肽的抗肿瘤侵袭、转移活性。实验结果 ,RGD和YIGSR的杂叉肽和YIGSR的均叉肽对PG细胞较对照的YIGSR肽表现了更明显的粘附抑制作用 ,并降低了PG细胞的体外侵袭能力 ,降低了移值Lewis肺癌细胞肺转移小鼠的肺重量或肺转移瘤结节数 ,但对小鼠原发部位移植瘤重量无明显影响 ;YIGSR聚合肽的以上作用有一定的剂量依赖性。
The anti-tumor invasiveness and metastasis activity of YIGSR homografts and cross-polymeric peptides were studied using high metastatic tumor cells in vitro adhesion and invasion models of basement membrane components and spontaneous lung metastasis models of Lewis lung cancer cells. The experimental results showed that the cross-linked peptides of RGD and YIGSR and the YIGSR fork peptides showed more pronounced adhesion inhibition to PG cells compared with the control YIGSR peptides, and decreased the invasive ability of PG cells in vitro, and reduced the migration of Lewis lung cancer. The lung weight of pulmonary metastatic mice or the number of lung metastatic nodules did not have a significant effect on the weight of transplanted tumors at the primary site; the above effects of YIGSR poly peptides were dose-dependent.