论文部分内容阅读
纤维粘着蛋白(Fibronectin,Fn)是一种大分子糖蛋白,存在于体液和软组织的基质及大多数的基底膜中,以血浆中含量为最高,达300μg/ml。Fn具有多种调节功能,它参与细胞与胞外物质间的作用,包括细胞与固体基质的粘连,构成细胞的骨架;细胞的趋化或趋合(haptotaxis)游走;肿瘤转移;止血与血栓形成及介导非特异性吞噬作用等。因此它在细菌与宿主细胞间的作用上日益受到注意。一、Fn的分子结构及功能血浆中及细胞上的Fn结构均相似,为高分子糖蛋白,分子量约为440,000道尔
Fibronectin (Fn) is a macromolecule glycoprotein that is found in the body fluids and soft tissue matrices and most basement membranes, with the highest plasma levels of 300 μg / ml. Fn has a variety of regulatory functions that are involved in the interactions between cells and extracellular materials, including adhesion of cells to solid matrices, formation of cellular skeletons, chemotaxis or haptotaxis migration of cells, tumor metastasis, hemostasis and thrombus Formation and mediation of non-specific phagocytosis and so on. It is therefore gaining more attention in the role of bacteria and host cells. First, Fn’s molecular structure and function Fn plasma and cell structure are similar to the polymer glycoprotein, molecular weight of about 440,000 Dole