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目的:探究替格瑞洛联合阿司匹林对老年急性心肌梗死(AMI)患者血小板功能及预后的影响。方法:选择我院112例老年AMI患者,随机分组,各56例。对照组应用氯吡格雷+阿司匹林治疗,观察组采用替格瑞洛+阿司匹林治疗,持续用药1年。检测对比两组治疗前、治疗2周后血小板反应指数(PRI)、血小板聚集率(MPA),并随访观察用药1年期间两组主要不良心血管事件(MACE)发生情况。结果:与对照组相比,观察组治疗2周后PRI、MPA均降低,差异具有统计学意义(P<0.05);1年随访期间,观察组MACE发生率(0.00%)显著低于对照组(10.71%),差异具有统计学意义(P<0.05)。结论:对老年急性心肌梗死患者联合应用替格瑞洛与阿司匹林治疗可有效抑制血小板功能,显著降低患者主要不良心血管事件发生率。
Objective: To investigate the effect of ticagrelor plus aspirin on platelet function and prognosis in elderly patients with acute myocardial infarction (AMI). Methods: One hundred and twelve elderly patients with AMI in our hospital were randomly divided into two groups, 56 cases each. The control group was treated with clopidogrel plus aspirin. The observation group was treated with ticagrelor + aspirin for 1 year. The levels of platelet response index (PRI) and platelet aggregation rate (MPA) were measured before treatment and two weeks after treatment. The occurrence of MACE in both groups were observed and followed up for one year. Results: Compared with the control group, the PRI and MPA in the observation group decreased after 2 weeks of treatment, the difference was statistically significant (P <0.05). During the one-year follow-up, the incidence of MACE in the observation group was significantly lower than that of the control group (10.71%), the difference was statistically significant (P <0.05). Conclusion: The combination therapy of ticagrelor and aspirin in the elderly patients with acute myocardial infarction can effectively inhibit platelet function and significantly reduce the incidence of major adverse cardiovascular events.