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颗粒蛋白前体(PGRN)是一种多功能的分泌性生长因子,广泛表达于多种组织,尤其是快速生长的细胞中,参与胚胎发育、组织损伤修复、肿瘤发生、神经退行性变等病理生理过程。PGRN还是一个多功能的免疫调节分子,可以通过调节白细胞介素6(IL-6)信号途径,在肥胖和胰岛素抵抗性糖尿病小鼠模型中发挥促炎作用。与促炎作用相比,PGRN的抗炎作用更受关注,PGRN作为肿瘤坏死因子受体(TNFR)的一种新配体,能通过拮抗TNF-α信号通路、调节IL-10信号通路等,在类风湿性关节炎、炎症性肠病、银屑病等多种疾病中发挥抗炎作用。本文对PGRN在不同的炎症性疾病中的不同作用进行综述。
Progranulin (PGRN) is a multifunctional secretory growth factor that is widely expressed in many tissues, especially rapidly growing cells. It is involved in embryonic development, tissue damage repair, tumorigenesis and neurodegeneration Physiological process. PGRN is also a multifunctional immunomodulatory molecule that exerts a proinflammatory effect in obese and insulin resistant diabetic mouse models by modulating the interleukin 6 (IL-6) signaling pathway. The anti-inflammatory effect of PGRN is more concerned than the pro-inflammatory effect. As a new ligand of tumor necrosis factor receptor (TNFR), PGRN can antagonize TNF-α signaling pathway and regulate IL-10 signaling pathway, In rheumatoid arthritis, inflammatory bowel disease, psoriasis and other diseases play an anti-inflammatory effect. This article reviews the different roles of PGRN in different inflammatory diseases.