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自1963年Siegel首先发表有关每月一针避孕药的文章以来,已有许多关于其临床研究方面的资料,然而对这些制剂的药代动力学和药效学的研究很少,而有关这方面研究对临床使用前确定其合适剂量是很重要的。本文对Cycloprovera和HRP-102进行药代动力学和药效学的研究。月经规则健康妇女8例用Cycloprovera含甲孕酮(MPA)25mg+环戊丙酸雌二醇5mg,微晶悬浮剂;7例
Since the publication of the first monthly contraceptive pill by Siegel in 1963, there has been much information on its clinical research, however, little is known about the pharmacokinetics and pharmacodynamics of these preparations It is important that the study determine the appropriate dosage for clinical use. In this paper, Cycloprovera and HRP-102 pharmacokinetics and pharmacodynamics research. Menstrual regular 8 women with Cycloprovera methionone (MPA) 25mg + estradiol cypionate 5mg, microcrystalline suspending agent; 7 cases