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目的： 了解Ⅰ、Ⅲ型前胶原基因在增生性瘢痕（ Ｈ） 和瘢痕疙瘩（ Ｋ） 组织中表达的空间分布。方法： 非同位素原位杂交。结果： Ｋ 与 Ｈ 组织中Ⅰ型前胶原ｍ Ｒ Ｎ Ａ 表达均增强， Ｈ 中呈弥散分布， 而 Ｋ 中却主要位于网状真皮层的上部； Ⅲ型前胶原ｍ Ｒ Ｎ Ａ 表达增强仅见于 Ｈ 中。结论： Ｋ 和 Ｈ 组织中胶原蛋白基因表达强度及空间分布的差异可能是两者不同临床表现及生物学行为的分子病理学基础。
Objective: To investigate the spatial distribution of type Ⅰ and Ⅲ procollagen genes in hypertrophic scars (H) and keloids (K). Methods: Non-isotopic in situ hybridization. Results: The expression of type Ⅰ procollagen m R N A was increased in K and H tissues, but diffusely distributed in H and mainly located in the upper part of reticular dermis in K; the expression of type III procollagen m R N A was only seen in H. Conclusion: The difference of collagen gene expression intensity and spatial distribution in K and H tissues may be the molecular pathological basis of different clinical manifestations and biological behaviors.