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本文报告Ｂａｒｒｅｔｔ食道４２例，其中８例具有腺癌结构。内镜观察：食道粘膜上皮粗糙、糜烂、颗粒状增生、斑块状隆起、溃疡、粘膜充血或苍白。组织学观察：Ｂａｒｒｅｔｔ食道上皮有三种不同形态，其中胃底型上皮８例，交界型上皮１４例，特殊型上皮２０例，８例具有腺癌结构，特殊型上皮与腺癌结构间可见过渡形态。粘液组化染色观察：２０例特殊型上皮，ＨＩＤ（＋）１８例，８例具有腺癌结构的病例，ＡＢ、ＨＩＤ均呈不同程度的阳性。ＡｇＮＯＲ染色观察，Ｂａｒｒｅｔｔ食道三种上皮与食道腺癌平均每核含ＡｇＮＯＲ颗粒数相比均有非常显著的统计学差异（Ｐ＜０．０１）；观察结果提示：Ｂａｒｒｅｔｔ食道与食道腺癌关系密切，特殊上皮型Ｂａｒｒｅｔｔ食道可能是食道腺癌的癌前病变。
This article reports 42 cases of Barrett’s esophagus, of which 8 cases have an adenocarcinoma structure. Endoscopic observations: Esophageal mucosal epithelium rough, erosion, granular hyperplasia, plaque-like uplift, ulceration, mucosal hyperemia or pale. Histological observation: There are three different forms of Barrett’s esophageal epithelium, including 8 cases of gastric epithelium, 14 cases of borderline epithelium, 20 cases of special type epithelium, 8 cases of adenocarcinoma structure, transitional pattern between special type of epithelium and adenocarcinoma. . The results of mucin histochemical staining showed that there were 20 cases of special type epithelium, 18 cases of HID(+), and 8 cases of adenocarcinoma. The AB and HID were positive in different degrees. AgNOR staining showed that there was a statistically significant difference in the number of AgNOR particles per nuclei between Barrett’s esophagus and esophageal adenocarcinoma (P<0.01). The observational results suggest that Barrett’s esophagus is closely related to esophageal adenocarcinoma. The special epithelial Barrett esophagus may be a precancerous lesion of esophageal adenocarcinoma.