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室温下将磷酸盐缓冲液倒入含有药用级甘油三酯和非离子表面活性剂的无水混合物中可自发形成纳米乳。分别测定了6种不同理化性质的药物活性成分(API)在辅料中的表观溶解度,并表征了载API纳米乳的粒径、表面电位、药物回收率、p H值、渗透性、体外释药行为和稳定性,以考察制成静脉注射用纳米乳的成药性。结果表明,除环丙沙星(一种BCSⅣ类药物)外,其他API都能溶于至少一种辅料(如Labrasol)中。当API浓
Pour the nanoemulsion spontaneously by pouring the phosphate buffer into the anhydrous mixture containing the pharmaceutical grade triglyceride and the non-ionic surfactant at room temperature. The apparent solubility of six APIs with different physico-chemical properties in the excipients was determined and the particle size, surface potential, drug recovery, p H value, permeability, in vitro release Drug behavior and stability, in order to examine the drug-made nanoemulsion made into intravenous. The results showed that all the APIs except ciprofloxacin (a BCSIV drug) can be dissolved in at least one excipient (eg Labrasol). When API is rich