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本文选择11例确诊为十二指肠溃疡的20～24岁男性病人作试验对象。在前一晚禁食后,清晨进行研究。每例每周进行2次,共4次,随机轮流服用15(R)-15-甲基前列腺素 E_2(PGE_2)、Pamine(一种抗胆碱能药)、PGE_2加 Pamine 及安慰剂。在服药前先收集30分钟基础胃液,然后在分别服用上述药物后半小时进餐,进餐后每15分钟收集胃液一次,共2.5小时,分别测定其酸度,以 mEq/hr 表示。在开始收集基础胃液15分钟后、服药25分钟后以及在试餐试验过程中每隔30分钟收集血标本,用放射免疫法测定血清胃泌素浓度。结果见表1、2。
In this paper, 11 cases of 20-24-year-old male patients diagnosed as duodenal ulcer were selected as the test subjects. After fasting on the previous night, the study was conducted early in the morning. Each case was given 2 times a week for 4 times, taking 15 (R) -15-methyl prostaglandin E_2 (PGE 2), Pamine (an anticholinergic), PGE 2 plus Pamine and placebo randomly. Before taking the first collection of 30 minutes of gastric juice, and then taking the drug half an hour after meals, after meals every 15 minutes to collect gastric juice, a total of 2.5 hours, were measured for the acidity, in mEq / hr said. Serum gastrin levels were measured by radioimmunoassay 15 minutes after the start of collecting basal gastric juice, 25 minutes after taking the medication, and every 30 minutes during the test meal. The results are shown in Tables 1 and 2.