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目的比较脂肪肝或丙氨酸氨基转移酶异常的患者中代谢异常的患病情况,探讨两者对代谢的影响。方法以上海宝钢集团股份公司2001年1月～2002年12月参加体检的职工为研究对象,应用SPSS11.5软件进行统计处理。结果在该研究人群中,脂肪肝的患病率为14.08%,其中非酒精性脂肪性肝病(NAFLD)的患病率为11.16%;转氨酶异常的患病率为3.17%,脂肪肝患者中转氨酶异常的患病率为11.7%,转氨酶异常的患者中脂肪肝患病率为51.9%。根据是否患有脂肪肝和转氨酶异常,将研究人群分组后,发现在转氨酶异常的两组间(伴有和不伴有脂肪肝),性别、年龄、体重指数(BMI)、收缩压、舒张压以及肥胖的患病率无差异,但伴有脂肪肝组的血脂、血糖、血红蛋白的水平以及高血压、高脂血症和空腹血糖异常(IFG)及糖尿病的患病率明显高于无脂肪肝组(P<0.01);而在患有脂肪肝两组间(伴有和不伴有转氨酶异常),转氨酶异常组的年龄、BMI、血压和血红蛋白的水平以及肥胖和高血压的患病率高于转氨酶正常组(P<0.01),而血脂、血糖的水平及高脂血症、IFG、糖尿病的患病率两组间无差异。结论单纯脂肪肝对血脂、血糖的影响要大于其对BMI、血压的影响。脂肪肝患者出现转氨酶异常,可能不仅仅是肝脏损伤的表现,还可能是年龄增长、肥胖和高血压加重的表现。
Objective To compare the prevalence of metabolic abnormalities in patients with abnormal fatty liver or alanine aminotransferase and to explore their effects on metabolism. Methods The employees who took part in the physical examination from January 2001 to December 2002 in Shanghai Baosteel Group Corporation were selected as the research objects and SPSS 11.5 software was used for statistical analysis. Results In the study population, the prevalence of fatty liver was 14.08%, of which 11.16% was non-alcoholic fatty liver disease (NAFLD). The prevalence of abnormal aminotransferase was 3.17%. In patients with fatty liver, the transaminase The prevalence of abnormalities was 11.7%, and the prevalence of fatty liver in patients with abnormal aminotransferases was 51.9%. According to whether there is abnormality of fatty liver and aminotransferase, the study population was divided into groups and found that there was no significant difference in ALT between the two groups (with and without fatty liver), gender, age, body mass index (BMI), systolic blood pressure, diastolic blood pressure And the prevalence of obesity was no difference, but the levels of blood lipids, blood glucose, hemoglobin and the prevalence of hypertension, hyperlipidemia and fasting blood glucose (IFG) and diabetes in patients with fatty liver were significantly higher than those without fatty liver (P <0.01). However, the age, BMI, blood pressure and hemoglobin level, as well as the prevalence of obesity and hypertension were significantly higher in patients with fatty liver between the two groups (with and without transaminase abnormalities) (P <0.01). There was no difference between the two groups in the levels of blood lipids, blood glucose, hyperlipidemia, IFG and diabetes mellitus. Conclusion The effect of simple fatty liver on blood lipid and blood sugar is greater than that of BMI and blood pressure. Abnormal ALT in patients with fatty liver may not only be a manifestation of liver damage but may also be an indication of increased age, obesity and hypertension.