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目的 探讨白细胞介素 -6(IL -6)、白细胞介素 -8(IL -8)、白细胞介素 -13 (IL -13 )在狼疮性肾炎 (LN)患者中的变化及临床意义。方法 采用酶联免疫吸附法 (ELISA)检测 5 6例LN患者血清IL -6、IL -8、IL -13含量。结果 活动期LN患者血清IL -6、IL -8、IL -13含量显著高于非活动期组与正常对照组 (P <0 0 1) ,非活动期组LN患者血清IL -6、IL -8、IL -13含量与正常对照组比较无显著性差异 (P >0 0 5 ) ,活动期组LN患者血清IL -6、IL -8、IL -13的含量与抗双链DNA滴度、血沉呈显著正相关(P <0 0 1,P <0 0 5 ) ,而与补体C3 、补体C4则呈显著负相关 (P <0 0 1)。结论 IL -6、IL -8、IL -13可能参与了LN的发病过程 ,可作为LN患者狼疮活跃的临床参考指标 ,对于指导治疗及改善预后有重要意义。
Objective To investigate the changes and clinical significance of interleukin-6 (IL-6), interleukin-8 (IL-8) and interleukin-13 (IL-13) in patients with lupus nephritis (LN). Methods Serum levels of IL-6, IL-8 and IL-13 in 56 patients with LN were detected by enzyme linked immunosorbent assay (ELISA). Results The serum levels of IL - 6, IL - 8 and IL - 13 in active LN patients were significantly higher than those in inactive patients and normal controls (P <0.01). The levels of IL - 6 and IL - 8, IL-13 levels in normal control group had no significant difference (P> 0.05). The levels of IL-6, IL-8 and IL- There was a significant positive correlation between erythrocyte sedimentation rate and erythrocyte sedimentation rate (P <0.01, P <0.05), but negatively correlated with complement C3 and complement C4 (P <0.01). Conclusion IL-6, IL-8 and IL-13 may be involved in the pathogenesis of LN and may be used as an active clinical reference for lupus in patients with LN, which is of great significance for guiding treatment and improving prognosis.