重症肌无力(MG)是一种主要累及神经-肌肉接头突触后膜乙酰胆碱受体的获得性自身免疫性疾病。临床上主要表现为部分或全身骨骼肌无力和极易疲劳,活动后加重,经休息和胆碱酯酶抑制剂治疗后症状减轻。大多数MG患者可见胸腺病理改变。研究表明,胸腺病毒感染及慢性炎症刺激、异常免疫激活、胸腺中枢耐受性破坏及免疫调节失衡参与了MG的发生和发展过程。 Myasthenia Gravis (MG) is an acquired autoimmune disease that mainly affects the postsynaptic acetylcholine receptor of the neuromuscular junction. Mainly manifested as clinically part or whole body skeletal muscle weakness and fatigue, aggravating after exercise, after resting and cholinesterase inhibitors reduce symptoms. Thymus pathology can be seen in most MG patients. Studies have shown that thymovirus infection and chronic inflammation, abnormal immune activation, thymus tolerance to damage and immune imbalance in the pathogenesis and development of MG.