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目的探讨长效皮质类固醇激素曲安奈德局部注射治疗泪腺炎的效果。方法自2002年6月-2005年9月对10例不愿或不能接受全身激素治疗的患者采取曲安奈德局部注射的方法进行治疗,10例患者均为单侧泪腺炎。取曲安奈德混悬液20mg(0.5ml)加2%利多卡因0.5ml注射于眶外上缘泪腺组织内,局部加压20分钟,隔周后重复注射至病情稳定或局部肿块消失,最多注射5次。结果10例中5例(其中4例为第一次发病,1例曾有过2次复发)患者注射3-5次后治愈,观察6个月-3年未见复发;3例患者(均有过2次以上复发病史者)注射后好转,其中1例又复发2次在再次注射曲安奈德后病情稳定;2例有过多次复发史且多次不规律用口服激素治疗的患者局部注射5次无效,且因反复发作最后接受手术摘除泪腺。结论曲安奈德局部注射治疗泪腺炎对于不愿接受或全身情况不允许大剂量激素治疗的患者为一可行而有效的方法,尤其对于初次发病的患者效果显著。
Objective To investigate the effect of long-acting corticosteroid triamcinolone acetonide for the treatment of lacrimal gland inflammation. Methods From June 2002 to September 2005, 10 patients who were unwilling or unable to receive systemic hormonal therapy were treated with local injection of triamcinolone acetonide. All 10 patients were unilateral lacrimal gland inflammation. Take triamcinolone acetonide suspension 20mg (0.5ml) plus 2% lidocaine 0.5ml injection in the supraorbital lacrimal gland tissue, local pressure for 20 minutes, repeated weeks after injection to the stable condition or local mass disappeared, the most Injection 5 times. Results Of the 10 cases, 5 cases (4 cases had the first disease and 1 case had 2 recurrences) were cured after 3 to 5 times of injection. No recurrence was observed after 6 months to 3 years. All 3 patients Had a history of more than 2 times of recurrence) improved after injection, of which 1 case relapsed 2 times after re-injection of triamcinolone in stable condition; 2 cases had multiple recurrences and many irregularities with oral hormone treatment of patients with local Injection 5 times invalid, and because of recurrent episodes of surgery to remove lacrimal glands. Conclusions Local injection of triamcinolone acetonide for the treatment of dacryoadenitis is a feasible and effective method for patients who are unwilling to accept or not tolerated high-dose hormone therapy in general conditions, especially for patients with initial onset.