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健康成年人自愿受试者１０例，随机分为３组，分别住院静脉注射加贝酯２００ｍｇ／ｄ、３００ｍｇ／ｄ、４００ｍｇ／ｄ。结果除高浓度（３００ｍｇ加贝酯溶于５％Ｇ－Ｓ５００ｍｌ）组，在滴速６０滴／ｍｉｎ时，１例出现局部发红，疼痛及２例于停药后１周出现轻度表浅静脉炎外，未发现过敏，血压下降，ＥＣＧ改变，肝、肾功能损伤等其它不良反应，说明国产加贝酯注射剂临床应用安全，成人每ｄ可用１００～４００ｍｇ，以１００～２００ｍｇ溶于５％葡萄糖液５００ｍｌ静滴为宜，但１０例中有６例（６０％）因药液外渗，引起局部刺激症状，故应尽量避免高浓度，快速静滴，并防止液体外溢皮下。
Healthy volunteers 10 volunteers were randomly divided into three groups, respectively, hospitalized intravenous administration of Gaboxylate 200mg / d, 300mg / d, 400mg / d. Results In addition to the high concentration (300mg gabionate dissolved in 5% G-S500ml) group, there was a local redness and pain in one case at a drip rate of 60 drops / min and two cases showed mild superficial Phlebitis, no allergies, blood pressure drop, ECG changes, liver and kidney dysfunction and other adverse reactions, indicating that domestic Jia Beisuan injection clinical application of safety, adult d every available 100 ~ 400mg, 100 ~ 200mg dissolved in 5% 500ml intravenous drip glucose solution is appropriate, but in 10 cases, 6 cases (60%) due to liquid extravasation, causing local irritation, it should try to avoid high concentrations, rapid intravenous drip and prevent liquid spill subcutaneous.