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非小细胞肺癌(Non-small cell lung cancer)NSCLC占肺癌的75%～80%,5年生存率在过去几十年里一直不超过15%。AKT是一种丝氨酸/苏氨酸蛋白激酶,又名蛋白激酶B,是原癌基因C-AKT的表达产物,参与癌细胞PI3K介导的信号传导过程,且处于此信号通路的枢纽位置。T-308和S-473两个位点的同时磷酸化是AKT的活化形式。活化的AKT在抑制细胞的凋亡,促进细胞的运动,促进细胞的增殖及肿瘤的侵袭方面起着重要的作用,它与NSCLC的发生发展密切相关。
Non-small cell lung cancer (NSCLC) accounts for 75% to 80% of lung cancers. The 5-year survival rate has not exceeded 15% in the past few decades. AKT is a serine / threonine protein kinase, also known as protein kinase B, which is the expression product of proto-oncogene C-AKT, which is involved in the PI3K-mediated signal transduction of cancer cells and is located at the pivotal position of this signaling pathway. Phosphorylation of both T-308 and S-473 sites is an activated form of AKT. Activated AKT plays an important role in inhibiting cell apoptosis, promoting cell motility, promoting cell proliferation and tumor invasion. It is closely related to the occurrence and development of NSCLC.