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用核磁共振方法研究了 β CD与三种菁染料 3,3′ 二 (3 磺丙基 )噻菁三乙胺盐(dyeA)、3,3′ 二 (3 磺丙基 ) 5 氯 噻菁三乙胺盐 (dyeB)和 3,3′ 二 (3 磺丙基 ) 5,5′ 二苯基 9 乙基恶碳菁 (dyeC)在溶液中的包合现象和包合物的动态结构 ,实验发现 β CD环糊精疏水腔中的H 3和H 5以及三种菁染料的芳环上质子的化学位移由于形成包合物而发生明显变化 ,而且峰的位置随包合程度的不同而不同 .实验中发现包合物的荧光强度随 β CD浓度增加而减弱 ,相应计算表明 β CD与三种菁染料形成了 1∶1的包合物 .本文研究了三种包合物中主体部分OH 3和OH 6的化学位移随温度变化的情况 ,获得了包合物中氢键强弱的信息 ,通过NMR化学位移滴定法计算得到了三种包合物在水溶液中的稳定常数 ,在上述工作的基础上 ,本文提出了三种包合物的结构模型 ,描述了客体进入主体腔中的动态过程 .
The interaction of β CD with three cyanine dyes, 3,3 ’bis (3-sulfopropyl) thiacetyl triethylamine (dyeA), 3,3’ bis Inclusion phenomenon of ethylamine salt (dyeB) and 3,3 ’bis (3-sulfopropyl) 5,5’ diphenyl 9 ethylcarbacarbocyanide (dyeC) in solution and the dynamic structure of inclusion complex, It was found that the chemical shifts of H 3 and H 5 in the β CD cyclodehydrin hydrophobic cavity and the aromatic rings on the aromatic rings of the three cyanine dyes changed significantly due to the inclusion complex formation and the positions of the peaks differed depending on the degree of inclusion It was found that the fluorescence intensity of the inclusion complex decreased with the increase of β CD concentration, and the corresponding calculation indicated that β CD forms a 1: 1 inclusion complex with the three cyanine dyes.In this paper, the main part OH 3 and OH 6 with the temperature changes, we get the information about the strength of the hydrogen bonds in the inclusion complex. The stability constants of the three kinds of inclusion complexes in aqueous solution were obtained by NMR chemical shift titration. In the above work Based on this, we propose the structural model of three clathrates, and describe the dynamic process of the object entering the body cavity.