随着经济发展与人口老龄化,外周血管疾病的发病率逐年上升。血小板的黏附、激活和聚集在外周血管疾病发生和发展进程中起着重要的作用,通过有效的抗血小板治疗,能够显著降低这些病人心血管事件的发生率。对存在高危因素的病人,采用抗血小板药物进行二级预防能够有效减少心血管事件的发生。然而对于有些病人,抗血小板治疗并不能取得理想的疗效,反而增加了出血的风险,应引进重视。 With the economic development and population aging, the incidence of peripheral vascular diseases increased year by year. Platelet adhesion, activation and aggregation plays an important role in the occurrence and development of peripheral vascular diseases. The effective anti-platelet therapy can significantly reduce the incidence of cardiovascular events in these patients. For patients with high risk factors, the use of antiplatelet drugs for secondary prevention can effectively reduce the incidence of cardiovascular events. However, for some patients, antiplatelet therapy can not achieve the desired effect, but increases the risk of bleeding, which should be taken into consideration.