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目的:探讨MHT治疗围绝经期综合征的依从性、安全性和临床疗效,以探索适应妇女群体接受的更年期保健模式。方法:选择102例符合纳入标准的患者,采取知情同意、自愿原则参加MHT的治疗,观察临床不良反应、临床疗效及依从性。结果:102例患者中,依从性好的65例(依从率63.73%),37例患者中途停止治疗,依从性好坏主要跟文化程度有关,而与年龄、症状轻重、居住地、职业等无明显关系;患者在使用MHT治疗6个月随访时在潮热、失眠、情绪波动及kupperman总评分上改善都有显著性(P<0.01),肝肾功能无明显改变(P>0.05),而总胆固醇、空腹血糖、低密度脂蛋白有明显下降(P<0.05),子宫肌瘤、乳腺结节患者B超复查无明显改变(P>0.05)。结论:围绝经期窗口期MHT治疗,不仅有效缓解围绝经期综合征,短期内降低胆固醇和低密度脂蛋白,而对肝肾功能、子宫肌瘤、乳腺结节的影响不明显,要进一步加强健康教育,普及围绝经期保健知识,提高MHT治疗的依从性。
OBJECTIVE: To investigate the compliance, safety and clinical efficacy of MHT in the treatment of perimenopausal syndrome in order to explore the modalities of menopause care for women. Methods: A total of 102 patients who met the inclusion criteria were enrolled in the study. Patients with MHT were taken informed consent and voluntary principle. Clinical adverse reactions, clinical efficacy and compliance were observed. Results: Among the 102 patients, 65 patients were obedient (compliance rate was 63.73%), and 37 patients stopped treatment. The compliance was mainly related to education level, but not related to age, severity of symptoms, residency and occupation (P <0.01). There was no significant change in liver and kidney function (P> 0.05), but there was significant difference between the two groups (P> 0.05) Total cholesterol, fasting blood glucose, low density lipoprotein were significantly decreased (P <0.05), uterine fibroids, breast nodules in patients with B-ultrasound did not change significantly (P> 0.05). Conclusion: The peri-menopausal window MHT treatment not only effectively relieves perimenopausal syndrome, short-term cholesterol and low density lipoprotein, but has no obvious effect on liver and kidney function, uterine fibroids and breast nodules, and should be further strengthened Health education, universal perimenopausal knowledge of health, improve the compliance of MHT treatment.