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目的 进一步探讨肠道病毒感染与克山病发病的关系。方法 应用免疫组织化学等方法对克山病患者心肌组织标本进行肠道病毒检测并与其他疾病进行对比。结果 在 11例克山病患者中发现 9例病毒结构蛋白VP1阳性 ,其中 8例同时检测到病毒RNA ;而 8例缺血性心肌病仅 3例VP1阳性 ,其中 2例RNA也阳性。 3例死于其他疾病患者未发现肠道病毒。结论 克山病患者心肌组织中不仅存在肠道病毒基因RNA ,而且也有其表达的结构蛋白VP1,提示肠道病毒感染可能为克山病发病的主要原因之一。
Objective To explore the relationship between enterovirus infection and Keshan disease. Methods Immunohistochemistry and other methods were used to detect enterovirus in myocardial tissue of patients with Keshan disease and compared with other diseases. Results Nine cases of viral structural protein VP1 were found in 11 cases of Keshan disease, of which 8 cases detected viral RNA at the same time. Only 3 cases of VP1 were positive in 8 cases of ischemic cardiomyopathy, of which 2 cases were also positive for RNA. Three patients died of other diseases did not find enterovirus. Conclusion There is not only the RNA of enteroviral gene in myocardial tissue of Keshan disease, but also the structural protein VP1 expressed in Keshan disease, suggesting that enterovirus infection may be one of the major causes of Keshan disease.