广义的高血压,包括了体循环高压和肺循环高压(即肺动脉高压),无论其病因如何,最直接的血管生理改变均表现血管平滑肌细胞(VSMC)兴奋性增强导致的血管张力异常升高。血循环中激素、神经递质及内皮源性因子等各种扩血管和缩血管物质作用于血管平滑肌细胞,引起其兴奋性的改变,从而 Generalized hypertension, including systemic hypertension and pulmonary hypertension (ie, pulmonary hypertension), regardless of etiology, the most direct changes in vascular physiology are characterized by vascular excitability of vascular smooth muscle cells (VSMC) increased vascular tension abnormalities. Circulation of hormones, neurotransmitters and endothelium-derived factors and other vasodilators and vasoconstrictors in vascular smooth muscle cells, causing excitability changes, which