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目的探讨非小细胞肺癌（ＮＳＣＬＣ）中增殖细胞核抗原（ＰＣＮＡ）的表达及与一些临床指标的相关性。方法利用免疫组化ＡＢＣ法回顾性分析１９６４年１月～１９９４年１２月间中国医学科学院肿瘤医院开胸探查术后或纤维支气管镜活检术后单纯放射治疗的９５例非小细胞肺癌的ＰＣＮＡ表达情况。结果全部病例均有ＰＣＮＡ表达，ＰＣＮＡ指数（ＰＩ）值平均为０．５２３，统计分析ＰＩ值与ＮＳＣＬＣ原发灶所在部位、分型、分化、分期、放射敏感性及预后均无相关性，（Ｐ＞０．０５），但在分期分析中，有随分期愈晚，ＰＩ值逐渐增加的趋势。结论ＰＣＮＡ表达与非小细胞肺癌原发部位、分型、放射敏感性及预后无明显相关性；与分期、分化的相关性有待继续探讨。
Objective To investigate the expression of proliferating cell nuclear antigen (PCNA) in non-small cell lung cancer (NSCLC) and its correlation with clinical parameters. Methods Immunohistochemical ABC method was used to retrospectively analyze the expression of PCNA in 95 cases of non-small cell lung cancer (NSCLC) treated with radiotherapy after open-chest exploration or fiberoptic bronchoscopy biopsy between January 1964 and December 1994 in Chinese Academy of Medical Sciences. Happening. Results PCNA expression was found in all cases. The average PCNA index (PI) was 0.523. There was no correlation between the statistical analysis of PI and the location, type, differentiation, staging, radiosensitivity, and prognosis of NSCLC primary lesions. P>0.05), but in the stage analysis, the PI value gradually increases with the later stage. Conclusion There is no significant correlation between the expression of PCNA and the primary site, type, radiosensitivity and prognosis of NSCLC. The correlation with PCNA expression and staging and differentiation remains to be discussed.