目的探讨定君生(乳杆菌活菌胶囊)配合克霉唑联合治疗妊娠期外阴阴道假丝酵母菌病的效果。方法将门诊中360例妊娠期外阴阴道假丝酵母菌病的患者随机分为观察组(定君生配合克霉唑治疗)、对照组(单用克霉唑治疗)分别观察两组的疗效和复发性。结果治疗结束后2周复查,观察组和对照组均有较好的疗效,治愈率分别为81.1%、76.1%;有效率分别为93.1%、87.2%,两组间治愈率和有效率的差异无统计学意义(P>0.05)。治疗结束后4周复查,观察组疗效明显高于对照组,治愈率分别为78.2%、51.5%;有效率分别为91.1%、66.1%,两组间治愈率和有效率的差异有统计学意义(P<0.05)。治疗结束后2月复查,观察组疗效明显高于对照组,治愈率分别为77.8%、45.6%;有效率分别为90.1%、56.7%,两组间治愈率和有效率的差异有统计学意义(P<0.05)。结论克霉唑是治疗妊娠期外阴阴道假丝酵母菌病的有效药物,定君生配合克霉唑治疗妊娠期外阴阴道假丝酵母菌病具有增强疗效、减少复发的优点。 Objective To investigate the effect of Ding Jun Sheng (Lactobacillus live capsule) combined with clotrimazole in the treatment of vulvovaginal candidiasis during pregnancy. Methods A total of 360 outpatients with vulvovaginal candidiasis during pregnancy were randomly divided into observation group (treated with clonazole) and control group (treated with clotrimazole alone) Recurrent. Results Two weeks after the end of treatment, the observation group and the control group had good curative effect, the cure rates were 81.1% and 76.1% respectively; the effective rates were 93.1% and 87.2% respectively. The difference between the two groups in cure rate and effective rate No statistical significance (P> 0.05). 4 weeks after the end of treatment, the observation group was significantly higher than the control group, the cure rates were 78.2%, 51.5%; the effective rates were 91.1%, 66.1%, the cure rate and effective rate between the two groups were statistically significant (P <0.05). The curative effect in the observation group was significantly higher than that in the control group after 2 months of treatment, the cure rates were 77.8% and 45.6%, respectively. The effective rates were 90.1% and 56.7% respectively. There was significant difference between the two groups in cure rate and effective rate (P <0.05). Conclusion Clotrimazole is an effective drug for the treatment of vulvovaginal candidiasis during pregnancy. The combination of clonazocidine and clotrimazole for the treatment of vulvovaginal candidiasis during pregnancy has the advantage of reducing the recurrence.