目的　探讨凋亡相关基因ｂｃｌ－２ 基因和Ｂａｘ 基因在肺癌中的表达。方法　应用原位杂交技术检测了３８ 例肺癌组织及２１例肺部良性组织ｂｃｌ－２ ｍ ＲＮＡ表达情况；应用免疫组织化学法对Ｂａｘ 蛋白进行检测。结果　肺癌组织ｂｃｌ－２基因、Ｂａｘ 蛋白的表达（４２．１％ 、３４．２％ ）明显高于肺部良性组织（４．８％ 、０）Ｐ＜ ０．０１。结论　ｂｃｌ－２、Ｂａｘ蛋白在肺癌中的表达率较高，ｂｃｌ－２、Ｂａｘ 可能会成为肺癌的重要分子标志物。 Objective To investigate the expression of apoptosis-related genes bcl-2 and Bax in lung cancer. Methods In situ hybridization was used to detect the expression of bcl-2 mRNA in 38 lung cancer tissues and 21 lung benign tissues. Bax protein was detected by immunohistochemistry. Results The expression of bcl-2 gene and Bax protein in lung cancer tissues (42.1%, 34.2%) was significantly higher than that in lung benign tissues (4.8%, 0) P<0.01. Conclusion The expression rates of bcl-2 and Bax proteins in lung cancer are high, and bcl-2 and Bax may become important molecular markers of lung cancer.