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目的探讨梅毒孕妇分娩的新生儿血清学的影响,为梅毒治疗提供重要的参考依据。方法抽取广东东莞市太平人民医院产科2010-2012年收治的80例梅毒孕妇作为研究对象,并随机将其分娩的新生儿分为对照组和观察组各40例,其中观察组均在≤24孕周前治疗,对照组均在24孕周至分娩前2周接受治疗,比较和分析两组分娩新生儿的梅毒血清学和随访特点。结果观察组新生儿血清学均在治疗9个月内转为阴性,转阴率为100%;对照组新生儿血清学在随访15个月内中,仅有36例转为阴性,转阴率为90.0%,比较差异有统计学意义(P<0.05)。结论在梅毒孕妇分娩的新生儿血清学的随访过程中,尽早给予患者抗梅毒规则治疗,能够实现对先天性梅毒的发生情况进行有效控制,并缩短随访时间,具有较高的参考价值,值得在临床上推广应用。
Objective To investigate the serological effects of syphilis in neonates during delivery and provide an important reference for the treatment of syphilis. Methods Totally 80 pregnant women with syphilis admitted from 2010 to 2012 in Taiping People’s Hospital of Dongguan City of Guangdong Province were selected as study subjects and were divided randomly into control group and observation group of 40 newborns, Weeks before treatment, the control group were 24 weeks pregnant until 2 weeks before delivery to receive treatment, comparison and analysis of two groups of neonates with syphilis serological and follow-up characteristics. Results Serum of neonates in the observation group turned negative within 9 months of treatment, and the negative conversion rate was 100%. In the control group, among the 15 months of follow-up, only 36 cases turned negative and the negative conversion rate Was 90.0%, the difference was statistically significant (P <0.05). Conclusion In the course of serological follow-up of newborns with syphilis, it is of high value for reference to control the occurrence of congenital syphilis and shorten the follow-up time as soon as possible. Clinical application.