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目的:观察局部注射辅助口服药物治疗早期带状疱疹病理性神经痛的疗效和安全性。方法:60例早期带状疱疹性神经痛的病人,按入组顺序随机分为2组:A组:口服抗病毒药物,抑制病理性神经痛药物和镇痛药物治疗。B组:口服抗病毒药物,抑制病理性神经痛药物,镇痛药物联合疱疹局部注射治疗。观察患者辅助局部注射治疗前、治疗后3、7、14及28天的疼痛程度、镇痛药物使用量、药物副作用、治疗并发症等情况变化。结果:2组治疗后的NRS评分均降低((P﹤0.05);B组患者经局部注射治疗后,患者疼痛明显缓解,镇痛药物使用量明显减少,药物副作用明显减轻,无明显并发症。B组NRS评分均较A组明显降低,差异有显著性(P﹤0.05)。不良反应主要是局部淤血,头晕和嗜睡。结论:口服药物联合局部注射迅速减轻疼痛,可降低镇痛药的使用量,并减少其副作用,是带状疱疹的一种安全、有效的辅助治疗方法。
Objective: To observe the efficacy and safety of topical injection of oral medication for the treatment of pathological neuralgia of early herpes zoster. Methods: Sixty patients with early herpes zoster neuralgia were randomly divided into two groups according to the order of admission: group A: oral antiviral drugs, anti-pathological neuralgia drugs and analgesic drugs. Group B: oral antiviral drugs, inhibition of pathological neuralgia drugs, analgesics and herpes local injection therapy. Observe the changes of pain level, analgesic drug usage, drug side effects, treatment complications, etc. before, 3, 7, 14 and 28 days after auxiliary injection assisted by local injection. Results: After treatment, the NRS scores of both groups were decreased (P <0.05). After the local injection, the patients in group B relieved pain obviously, the dosage of analgesic drugs decreased obviously, and the side effects of drugs were obviously reduced without obvious complication. The NRS scores in group B were significantly lower than those in group A (P <0.05) .The adverse reactions were mainly local congestion, dizziness and drowsiness.Conclusion: Oral administration combined with local injection can reduce the pain quickly and reduce the use of analgesics Quantity, and reduce its side effects, is a safe and effective adjuvant treatment of shingles.