临床研究发现慢性肾衰竭(CRF)患者中约有30%合并有神经、精神系统损害[1,2]特别是发展到进行维持性透析的患者,会发生不同程度的抑郁[3],抑郁已成为肾脏疾病终末期患者的主要心理问题,严重影响患者的生活质量[4],因此在慢性肾衰竭维持性血液透析患者中进行抑郁及焦虑状态调查,并对其影响因素进行分析有重要临床意义。近年来研究发现维持性血液透析患者普遍存在微炎症状态及高同型半胱氨酸血症,微炎 Clinical studies have found that about 30% of patients with chronic renal failure (CRF) have neurological and psychiatric impairment [1, 2], especially those who develop maintenance dialysis, experience varying degrees of depression [3], depression Therefore, it is of great clinical significance to investigate depression and anxiety in maintenance hemodialysis patients with chronic renal failure, and to analyze its influential factors . In recent years, the study found that patients with maintenance hemodialysis prevalence of micro-inflammation and hyperhomocysteinemia, micro-inflammation