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目的探讨桥本甲状腺炎Th1/Th2的平衡偏移及其在发病中的作用。方法选择2004-01～06中国医科大学附属第一医院21例桥本甲状腺炎(HT组)和45名健康人(对照组)为研究对象,应用流式细胞技术检测外周血淋巴细胞中CD4+CCR5+和CD4+CD30+细胞,以其各自百分比和平均荧光强度(MFI)作为反映Th1/Th2免疫应答强度的指标。结果HT组中CD4+CCR5+和CD4+CD30+细胞的百分比均高于对照组(P<0.05),而且二者的MFI都与甲状腺过氧化物酶抗体(TPOAb)的浓度呈正相关。结论在HT患者中CCR5+和CD30+的表达均增加,提示Th1和Th2细胞可能共同参与了HT的发病。
Objective To investigate the equilibrium shift of Th1 / Th2 in Hashimoto’s thyroiditis and its role in the pathogenesis. Methods Twenty-one Hashimoto’s thyroiditis (HT) and 45 healthy subjects (control group) from the First Affiliated Hospital of China Medical University from January 2004 to January 2006 were enrolled in this study. Flow cytometry was used to detect the percentage of CD4 + CCR5 + and CD4 + CD30 + cells, with their respective percentages and mean fluorescence intensity (MFI) as an indication of the intensity of the Th1 / Th2 immune response. Results The percentage of CD4 + CCR5 + and CD4 + CD30 + cells in HT group was higher than that in control group (P <0.05), and the MFI of both groups was positively correlated with the concentration of thyroid peroxidase antibody (TPOAb). Conclusion The expression of CCR5 + and CD30 + in HT patients are increased, suggesting that Th1 and Th2 cells may participate in the pathogenesis of HT.