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通过观测小鼠在超重 (2 g)环境中生存 2周后返回正常 (1g)环境后游泳行为模式的改变和再适应过程及乙酰亮氨酸 (Acetyl_DL_leucine ,AL)对其的影响 ,研究了超重和旋转对前庭功能的影响及AL对前庭代偿的影响 .结果表明 :超重刺激使动物的体重下降但摄食量上升 ,旋转刺激对动物体重和摄食量的影响低于超重刺激 ;正常小鼠入水后 2～3d即达到其最大游泳速度 ;超重刺激明显降低小鼠游泳的平衡能力 ,进入 1g环境 9～10d后可恢复到最大游泳速度 ;旋转刺激对游泳平衡能力的影响低于超重刺激 ,进入 1g环境 5～ 6d后可恢复其最大游泳速度 ;AL抑制超重组小鼠游泳平衡能力的恢复 ,比给药对照组延后 4d ;AL促进旋转组小鼠游泳平衡能力的恢复 ,比给药对照组提前恢复 2d .
By observing the effect of Acetyl_DL_leucine (AL) on the change of swimming behavior pattern and the adaptation process of mice after returning to normal (1g) environment after 2 weeks of survival in overweight (2 g) And rotation on the vestibular function and the effects of AL on vestibular compensation.The results showed that overweight stimulation decreased body weight but increased food intake, and the effect of rotational stimulation on body weight and food intake was lower than that of overweight stimulation. In normal mice After 2 ~ 3d to reach its maximum swimming speed; overweight stimulation significantly reduce the balance of swimming ability of mice into 1g environment 9 ~ 10d after the maximum swimming speed can be restored; rotational stimulation on swimming balance ability is lower than the overweight stimulation, enter 1g environment 5 ~ 6d after the maximum swimming speed can be restored; AL overweight mice swimming balance recovery, than the control group delayed 4d; AL promote swirling mice swimming balance recovery, compared with the control Group early recovery 2d.