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ＣＩ 994〔4 乙酰氨基 Ｎ (2′ 氨基苯基 ) 苯酰胺〕是一种地那林 (ｄｉｎａｌｉｎｅ)的新的口服类似物 ,对多种肿瘤都表现出明显的活性 ,其作用机制尚不清楚 ,但传统的抗肿瘤机制都不在其中。其化学结构如下 :Ⅰ期临床试验的目的在于 :(1)确定最大耐受剂量 (ＭＴＤ) ,提出
CI 994 [4 Acetamido N (2’-aminophenyl) benzamide] is a new oral analogue of dinaline that shows significant activity against a wide range of oncologies and its mechanism of action is unclear , But the traditional anti-tumor mechanisms are not included. Its chemical structure is as follows: Phase I clinical trials are intended to: (1) determine the maximum tolerated dose (MTD), put forward