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This study examined the effects of a combined surgery of sleeve gastrectomy (SG) and modified jejunoileal bypass (JIB) on the body weight,food intake,and the plasma levels of active glucagon-like peptide-1 (GLP-1) and total ghrelin of rats.Rats were divided into 3 groups in terms of different surgical protocol:SG-JIB (n=12),SG (n=12),JIB (n=12) and sham surgery groups (n=10).In SG-JIB group,rats was subjected to sleeve gastrectomy and end to side anastomosis of part of the jejunum (25 cm from the ligament of Treitz) to the ileum 25 cm proximal to the cecum.The body weight and food intake were evaluated during 10 consecutive weeks postoperatively.The levels of active GLP-1 and total ghrelin in the plasma of the rats were measured by ELISA assay.The results showed that the SG-JIB treated rats relative to SG- or JIB-treated ones produced a sustained reduction in food intake and weight gain.The level of active GLP-1 was elevated and total ghrelin level decreased in SG-JIB-treated rats as compared with SG- or JIB-treated ones.It was concluded that SG-JIB could efficiently reduce the body weight and food intake,alter obesity-related hormone levels of the rats,indicating that SG-JIB may be potentially used for the treatment of obesity.