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目的:探讨阿仑膦酸钠联合鲑鱼降钙素治疗老年人髋部骨质疏松性骨折的效果观察及对患者骨代谢的影响。方法:选择浙江新安国际医院于2016年1月至2019年12月行手术治疗的老年髋部骨质疏松性骨折患者86例，按照随机数字表法分为观察组43例与对照组43例。对照组患者给予鲑鱼降钙素治疗，观察组在对照组基础上结合阿仑膦酸钠治疗。两组患者疗程均为6个月。比较两组治疗前后血清钙和磷水平变化、髋关节Harris评分和骨代谢变化。结果:观察组治疗后血清钙和磷水平与对照组比较差异无统计学意义(均n P>0.05)；观察组治疗后髋关节Harris评分(87.10±3.46)分，高于对照组的(78.65±4.32)分(n t＝10.011，n P<0.05)；观察组治疗后血清I型胶原羧基末端肽交联β特殊序列(0.27±0.05)μg/L，低于对照组的(0.39±0.07)μg/L，而碱性磷酸酶(117.93±10.15)U/L，高于对照组的(98.32±8.97)U/L(n t＝9.147、9.493，均n P0.05). After treatment, the Harris score of hip joint in the observation group[(87.10±3.46)points] was higher than that in the control group [(78.65±4.32)points](n t=10.011, n P<0.05). The serum β-CTX [(0.27±0.05)μg/L] in the observation group was lower than that in the control group [(0.39±0.07)μg/L], while the ALP [(117.93±10.15)U/L] in the observation group was higher than that in the control group[(98.32±8.97)U/L], the differences were statistically significant(n t=9.147, 9.493, all n P<0.05).n Conclusion:Alendronate combined with salmon calcitonin can improve the bone metabolism of elderly patients with hip osteoporotic fracture, and improve the function of hip joint.