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1997年10月~1998年3月,从北京青年中分离到6株H1N1流感亚型毒株,经国家流感中心鉴定确认。将6株中的5株与1994~1997年3株(H1N1)国家代表株作血凝抑制交叉试验,5株的抗原性明显不同于A/桂防/10/94,抗原比均≥2。5株中的4株抗原性明显不同于A/京防/25/96;5株中的2株抗原性明显不同于A/京防/53/97。将6株H1N1流行株送日本WHO流感协作中心作多株H1N1毒株抗原性初步分析,6株抗原性既不同于A/日本山形/120/86和A/日本山形/32/89,也不同于国际代表株德国的A/拜恩州/07/95和南非的A/约翰内斯堡/82/96。表明H1N1流感亚型毒株自1994年以来抗原变异较大,需严密监测
From October 1997 to March 1998, 6 strains of H1N1 influenza subtypes were isolated from Beijing youth and confirmed by National Influenza Center. Five of 6 strains were crossed with 3 representative strains of H1N1 from 1994 to 1997. The antigenicity of 5 strains was significantly different from that of A / Guifang / 10/94, and the ratio of antigens was ≥2. Four of the five strains had significantly different antigenicity from A / Jing Fang / 25/96; two of the five strains had significantly different antigenicity from A / Jing Fang / 53/97. Six H1N1 strains were sent to Japan WHO Collaborating Center for Influenza A (H1N1) for antigenicity analysis. The antigenicity of the six strains was different from A / Yamagata / 120/86 and A / Yamagata / 32/89 respectively Internationally represented strain A / Aaron / 07/95 in Germany and A / Johannesburg / 82/96 in South Africa. The subtypes of H1N1 influenza viruses have shown a large variation in antigen since 1994 and need to be closely monitored