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１９９７年１０月～１９９８年３月，从北京青年中分离到６株Ｈ１Ｎ１流感亚型毒株，经国家流感中心鉴定确认。将６株中的５株与１９９４～１９９７年３株（Ｈ１Ｎ１）国家代表株作血凝抑制交叉试验，５株的抗原性明显不同于Ａ／桂防／１０／９４，抗原比均≥２。５株中的４株抗原性明显不同于Ａ／京防／２５／９６；５株中的２株抗原性明显不同于Ａ／京防／５３／９７。将６株Ｈ１Ｎ１流行株送日本ＷＨＯ流感协作中心作多株Ｈ１Ｎ１毒株抗原性初步分析，６株抗原性既不同于Ａ／日本山形／１２０／８６和Ａ／日本山形／３２／８９，也不同于国际代表株德国的Ａ／拜恩州／０７／９５和南非的Ａ／约翰内斯堡／８２／９６。表明Ｈ１Ｎ１流感亚型毒株自１９９４年以来抗原变异较大，需严密监测
From October 1997 to March 1998, 6 strains of H1N1 influenza subtypes were isolated from Beijing youth and confirmed by National Influenza Center. Five of 6 strains were crossed with 3 representative strains of H1N1 from 1994 to 1997. The antigenicity of 5 strains was significantly different from that of A / Guifang / 10/94, and the ratio of antigens was ≥2. Four of the five strains had significantly different antigenicity from A / Jing Fang / 25/96; two of the five strains had significantly different antigenicity from A / Jing Fang / 53/97. Six H1N1 strains were sent to Japan WHO Collaborating Center for Influenza A (H1N1) for antigenicity analysis. The antigenicity of the six strains was different from A / Yamagata / 120/86 and A / Yamagata / 32/89 respectively Internationally represented strain A / Aaron / 07/95 in Germany and A / Johannesburg / 82/96 in South Africa. The subtypes of H1N1 influenza viruses have shown a large variation in antigen since 1994 and need to be closely monitored